Ontology – Communicable Diseases Research

Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathway

Article

Published on 2023-01-302022-11-15
Journal: Journal of ethnopharmacology
[Category] 유전자 메커니즘, 진단,

Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review

Article

Published on 2022-11-012022-11-16
Journal: Annals of Clinical and Translational Neurology
[Category] 변종,

A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology

Article

Published on 2022-10-212022-11-16
Journal: Journal of Biomedical Semantics
[Category] COVID19(2023년), SARS, 변종, 신약개발,

[키워드] aligned Amino acid amino acid substitution Analysis applied basic Clinical data clinical trial coronavirus coronavirus coronavirus disease COVID-19 COVID-19 pandemic Delta Diagnosis diagnostic disease domain drug Drug repurposing drug-target effective Epidemiology evaluated example Formal global public health heterogeneous Human Infectious disease initiated knowledge Metadata omicron ontologies Ontology outbreak phenotype PPI protein-protein interaction Safe SARS-CoV-2 SARS-CoV-2 protein Standardization Support supported target protein Treatment Vaccine vaccine. variant variants variants of SARS-CoV-2 virus
[DOI] 10.1186/s13326-022-00279-z PMC 바로가기

Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host

Article

Published on 2022-10-012022-11-15
Journal: Computers in biology and medicine
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

[키워드] activity acute respiratory syndrome analyses Analysis Antiviral antiviral activity apoptosis pathway approach bind binding site Colon coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients effective endoribonuclease enrichment enrichment analysis evaluate Fortunellin generate Genetic growth Host identify immunomodulation immunomodulatory immunomodulatory capability Infection inherent inhibiting Invasion liver lung cell majority mechanism MM-GBSA analysis molecular molecular docking molecular dynamics Molecular dynamics simulation Multi-target mutability network network pharmacology NHBE Ontology Organoid pancreatic pathway per day pro-inflammatory cytokine protective immunity protein-protein interaction SARS-CoV-2 SARS-CoV-2. Support target target proteins targets the SARS-CoV-2 therapeutic tissue damage tissues treating COVID-19 viral replication virion virus
[DOI] 10.1016/j.compbiomed.2022.106049 PMC 바로가기

Preclinical findings: The pharmacological targets and molecular mechanisms of ferulic acid treatment for COVID-19 and osteosarcoma via targeting autophagy

Article

Published on 2022-09-202022-11-15
Journal: Frontiers in Endocrinology
[Category] SARS, 변종, 유전자 메커니즘, 진단,

[키워드] 2019 coronavirus disease activities acute respiratory disease applied autophagy Bioinformatics analysis characterized clinical coronavirus COVID-19 deficiency determine develop Effectiveness Evidence ferulic acid Genes impacted individuals MAPK1 mechanism mechanisms medication methodology molecular docking molecular docking analysis molecular mechanism network pharmacology number of infected Ontology osteosarcoma pandemic pathway enrichment Patient Patients with cancer pharmacological pharmacological target PIK3R1 Population potential therapeutic target Preclinical Protein regulatory subunit SARS-CoV-2 STAT3 target targets therapeutic therapeutic targets therapeutic targets. Transcription treat treatment for COVID-19 variant
[DOI] 10.3389/fendo.2022.971687 PMC 바로가기

Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Article

Published on 2022-09-162022-11-16
Journal: Frontiers in Immunology
[Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome analyses analysis Analysis approach bioinformatics bioinformatics analyses biological function caused CD8A Clinical practice collected Compound condition coronavirus COVID COVID-19 infection COVID-19 pandemic CXCL8 database dataset demonstrated develop discharge enrichment analysis Evidence fatigue Genes greater healthcare help hub protein identify IL-1B IL-6 Infection information Interaction Intersection Laboratory Long Long COVID ME/CFS mechanism multicenter Myalgic encephalomyelitis/chronic fatigue syndrome network analysis nine Ontology pathway enrichment performed PPI PPI network predicted protein-protein interaction Protein–protein interaction protein–protein interaction network required SARS-CoV-2 signaling pathway Symptom syndrome Systems biology systems biology. therapeutic drug TP53 Transcription transcription factor
[DOI] 10.3389/fimmu.2022.952987 PMC 바로가기

The striking mimics between COVID-19 and malaria: A review

Article

Published on 2022-08-232022-11-16
Journal: Frontiers in Immunology
[Category] SARS, 변종,

Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning and bioinformatics approaches

Article

Published on 2022-08-172022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 바이오마커, 치료기술, 치료제,

[키워드] acid approach bioinformatics caused Comorbidities complex interplay Compound contribute coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 progression Critical cyclosporine DEGs detect develop differentially expressed gene disease disease pathogenesis dysregulated E2F1 effort EGR1 expressed Factor functional functional enrichment Gene expression profiling Gene regulatory networks Genetic Genomics healthy controls healthy individual humans identify indicated individual individuals insight inter-individual Interaction machine learning approach MAX Mental mental retardation miRNA expression miRNAs nasopharyngeal network analysis offer Ontology overexpressed pandemic pathophysiology pathway pharmacological Potential biomarker Regulatory respiratory responsible reveal RNA-Seq RNA-seq data SARS-CoV-2 SARS-COV-2 infection Spread SRF TFS the SARS-CoV-2 therapeutic option therapeutic target therapeutic targets therapeutic targets. Vaccine Variability with COVID-19 YY1
[DOI] 10.3389/fimmu.2022.918692 PMC 바로가기

Developing a Long COVID Phenotype for Postacute COVID-19 in a National Primary Care Sentinel Cohort: Observational Retrospective Database Analysis

Observational Study

Published on 2022-08-112022-10-04
Journal: JMIR Public Health and Surveillance
[Category] 임상,

[키워드] 95% CI acute COVID-19 acute infection addition biomedical ontologies BioPortal Clinical characteristics clinical symptom clinically coded coding college Comorbidities complex computerized contribute COVID COVID-19 data accuracy data extracts data sets database develop Developing diagnosed Diagnosis Digital tool disease disease management Electronic health record English Epidemiology Ethnicity general practitioner General practitioners groups had no Health Hospital admission Hospitalization Hospitalized include individual Infection Laboratory Logistic regression Long Long COVID long-COVID management medical record systems nomenclature office ontological Ontology Oxford Patient phenotype postacute COVID-19 syndrome primary care problems public health RCGP recorded recruited Research retrospective RSC SARS-CoV-2 sentinel social class Sociodemographic Study protocol Surveillance surveillance. Symptom Systematized Nomenclature of Medicine used data Validity
[DOI] 10.2196/36989 PMC 바로가기 [Article Type] Observational Study

Identification of differentially expressed genes and their major pathways among the patient with COVID-19, cystic fibrosis, and chronic kidney disease

Research article

Published on 2022-08-072022-10-05
Journal: Informatics in Medicine Unlocked
[Category] 바이오마커, 변종,

[키워드] analysed analysis Analysis bioinformatics cause Chronic kidney disease CKD Comorbidity COVID-19 COVID-19 disease cystic fibrosis dataset differentially expressed gene Differentially expressed genes disease disease categories drug expression profiling fibrosis FOXN2 functional Gene regulatory networks help HNF4A identification identify indicated Infectious disease Interaction involved majority MicroRNAs Mild moderate Multiple Ontology pathophysiological pathway Patient patients with COVID-19 performed Potential biomarker predicted protein-protein interaction PRPF31 reducing regulated researcher respiratory symptoms RIOK3 SARS-CoV-2 SARS-CoV-2 virus System biology the patient therapeutic molecules transcription factor Transcriptomic profiling UBC upregulated upregulated genes virus was done with COVID-19
[DOI] 10.1016/j.imu.2022.101038 [Article Type] Research article